The UPDICE consortium met on the 19th of November at the University of Bristol to review recent progress across Work Packages 2 and 3, and Cross-cutting Activities 1 and 2. Updates for WP2/3 highlighted new laboratory and computational findings on the behaviour of molecules confined within supramolecular assemblies, as well as de novo and natural proteins. Recent publications on indole and tryptophan (CA1) have led to investigations into a wider range of related chromophores. The team presenting CA2 reported progress in time-resolved photoelectron spectroscopy using liquid jets and in fluorescence-lifetime measurements of organic solutes in water microdroplets.